Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.

@article{Kitayama1990GeneticAO,
  title={Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.},
  author={Hitoshi Kitayama and Takashi Matsuzaki and Yoji Ikawa and Makoto Noda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 11},
  pages={4284-8}
}
Kirsten-ras-revertant 1 (Krev-1) cDNA encodes a ras-related protein and exhibits an activity of inducing flat revertants at certain frequencies (2-5% of total transfectants) when introduced into a v-K-ras-transformed mouse NIH 3T3 cell line, DT. Toward understanding the mechanism of action of Krev-1 protein, we constructed a series of point mutants of Krev-1 cDNA and tested their biological activities in DT cells and HT1080 human fibrosarcoma cells harboring the activated N-ras gene… CONTINUE READING

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