Genetic analysis of the GABRA1 gene in patients with essential tremor.

@article{Deng2006GeneticAO,
  title={Genetic analysis of the GABRA1 gene in patients with essential tremor.},
  author={Hao Deng and Wen-jie Xie and Weidong Le and Mao-sheng Huang and Joseph Jankovic},
  journal={Neuroscience letters},
  year={2006},
  volume={401 1-2},
  pages={16-9}
}
The gamma-aminobutyric acid A (GABA-A) receptor mediates inhibitory neurotransmission in the brain and as such may be involved in certain neurological movement disorders, such as tremor. GABA-A receptor alpha 1 (Gabra)(-/-) mice have been reported to exhibit postural and kinetic, alcohol-responsive, tremor that is characteristic of essential tremor (ET), the most common form of tremor. To determine whether ET is associated with the GABRA1 gene mutation, we screened 76 patients with familial ET… CONTINUE READING
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