Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release.

@article{Pang2006GeneticAO,
  title={Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release.},
  author={Zhiping P Pang and Jianyuan Sun and Josep Rizo and Anton Maximov and Thomas C S{\"u}dhof},
  journal={The EMBO journal},
  year={2006},
  volume={25 10},
  pages={2039-50}
}
Synaptotagmin 2 resembles synaptotagmin 1, the Ca2+ sensor for fast neurotransmitter release in forebrain synapses, but little is known about synaptotagmin 2 function. Here, we describe a severely ataxic mouse strain that harbors a single, destabilizing amino-acid substitution (I377N) in synaptotagmin 2. In Calyx of Held synapses, this mutation causes a delay and a decrease in Ca2+-induced but not in hypertonic sucrose-induced release, suggesting that synaptotagmin 2 mediates Ca2+ triggering of… CONTINUE READING
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