Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice.

@article{Lipton1984GeneticAO,
  title={Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice.},
  author={Howard L. Lipton and R D Melvold},
  journal={Journal of immunology},
  year={1984},
  volume={132 4},
  pages={1821-5}
}
Genetic control of resistance and susceptibility to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice was examined. Mice derived from various crosses between susceptible SJL (S) and resistant C57BL/6 (B6) strains allowed determination of the relative susceptibility contributed by H-2 and non-H-2 genes, as well as allowing segregation of H-2 linked genes. Six of 39 B6SF1 hybrid progeny developed disease, suggesting several possibilities--resistance is dominant… CONTINUE READING

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