Genetic analysis of resistance and sensitivity to 2-deoxyglucose in Saccharomyces cerevisiae.

@article{McCartney2014GeneticAO,
  title={Genetic analysis of resistance and sensitivity to 2-deoxyglucose in Saccharomyces cerevisiae.},
  author={Rhonda R. McCartney and Dakshayini G Chandrashekarappa and Bob B Zhang and Martin Schmidt},
  journal={Genetics},
  year={2014},
  volume={198 2},
  pages={635-46}
}
Aerobic glycolysis is a metabolic pathway utilized by human cancer cells and also by yeast cells when they ferment glucose to ethanol. Both cancer cells and yeast cells are inhibited by the presence of low concentrations of 2-deoxyglucose (2DG). Genetic screens in yeast used resistance to 2-deoxyglucose to identify a small set of genes that function in regulating glucose metabolism. A recent high throughput screen for 2-deoxyglucose resistance identified a much larger set of seemingly unrelated… CONTINUE READING