Genetic analysis of polyketide synthase and peptide synthetase genes in cyanobacteria as a mining tool for secondary metabolites

@article{BarriosLlerena2007GeneticAO,
  title={Genetic analysis of polyketide synthase and peptide synthetase genes in cyanobacteria as a mining tool for secondary metabolites},
  author={Martin E. Barrios-Llerena and A. M. Burja and P. Wright},
  journal={Journal of Industrial Microbiology & Biotechnology},
  year={2007},
  volume={34},
  pages={443-456}
}
  • Martin E. Barrios-Llerena, A. M. Burja, P. Wright
  • Published 2007
  • Biology, Medicine
  • Journal of Industrial Microbiology & Biotechnology
  • Molecular screening using degenerate PCR to determine the presence of secondary metabolite genes in cyanobacteria was performed. This revealed 18 NRPS and 19 PKS genes in the 21 new cyanobacterial strains examined, representing three families of cyanobacteria (Nostocales, Chroococales and Oscillatoriales). A BLAST analysis shows that these genes have similarities to known cyanobacterial natural products. Analysis of the NRPS adenylation domain indicates the presence of novel features previously… CONTINUE READING
    50 Citations
    Diversity of non-ribosomal peptide synthetases genes in terrestrial streptomycetes
    Diversity of Polyketide Synthase (PKS) genes in metagenomic community of freshwater sponge Lubomirskia baicalensis
    • 8
    • Highly Influenced
    Molecular classification of commercial Spirulina strains and identification of their sulfolipid biosynthesis genes.
    • 7
    • PDF
    New approach for the detection of non-ribosomal peptide synthetase genes in Bacillus strains by polymerase chain reaction
    • 67
    Systems biology of cyanobacterial secondary metabolite production and its role in drug discovery
    • 42

    References

    SHOWING 1-10 OF 81 REFERENCES
    Distribution and Diversity of Natural Product Genes in Marine and Freshwater Cyanobacterial Cultures and Genomes
    • 114
    • PDF
    Characterization of the Nodularin Synthetase Gene Cluster and Proposed Theory of the Evolution of Cyanobacterial Hepatotoxins
    • 209
    • Highly Influential
    • PDF
    Discovery of a new peptide natural product by Streptomyces coelicolor genome mining
    • 301
    • PDF
    Molecular biology of peptide and polyketide biosynthesis in cyanobacteria
    • 88
    Evolutionary Affiliations Within the Superfamily of Ketosynthases Reflect Complex Pathway Associations
    • 87
    • Highly Influential
    Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.
    • 245