Genetic analysis of polyketide synthase and peptide synthetase genes in cyanobacteria as a mining tool for secondary metabolites

  title={Genetic analysis of polyketide synthase and peptide synthetase genes in cyanobacteria as a mining tool for secondary metabolites},
  author={Martin E. Barrios-Llerena and A. M. Burja and P. Wright},
  journal={Journal of Industrial Microbiology & Biotechnology},
  • Martin E. Barrios-Llerena, A. M. Burja, P. Wright
  • Published 2007
  • Biology, Medicine
  • Journal of Industrial Microbiology & Biotechnology
  • Molecular screening using degenerate PCR to determine the presence of secondary metabolite genes in cyanobacteria was performed. This revealed 18 NRPS and 19 PKS genes in the 21 new cyanobacterial strains examined, representing three families of cyanobacteria (Nostocales, Chroococales and Oscillatoriales). A BLAST analysis shows that these genes have similarities to known cyanobacterial natural products. Analysis of the NRPS adenylation domain indicates the presence of novel features previously… CONTINUE READING
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