Genetic analysis of pbp2x in clinical Streptococcus pneumoniae isolates in Quebec, Canada.

@article{Granger2005GeneticAO,
  title={Genetic analysis of pbp2x in clinical Streptococcus pneumoniae isolates in Quebec, Canada.},
  author={Dominic Granger and Genevi{\`e}ve Boily-Larouche and Pierre Turgeon and Karl Wei\ss and M. Roger},
  journal={The Journal of antimicrobial chemotherapy},
  year={2005},
  volume={55 6},
  pages={832-9}
}
OBJECTIVES To investigate the nature of the amino acid motifs found in penicillin-binding protein (PBP) 2x of penicillin-resistant Streptococcus pneumoniae isolates across the province of Quebec (Canada), and to obtain preliminary information regarding the prevalence of these alterations. METHODS The pbp2x genomic region encompassing codons 178-703, which includes the entire region of the transpeptidase domain, was sequenced and compared for 52 clinical isolates comprising 20 penicillin… CONTINUE READING
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