Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation.

@article{Perdiguero2007GeneticAO,
  title={Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation.},
  author={Eusebio Perdiguero and Vanessa Ruiz-Bonilla and Lionel Gresh and Lijian Hui and Esteban Ballestar and Pedro Sousa-Victor and Bernat Baeza-Raja and Merc{\`e} Jard{\'i} and Anna Bosch-Comas and Manel Esteller and Carm{\'e} Caelles and Antonio Serrano and Erwin F Wagner and Pura Mu{\~n}oz-C{\'a}noves},
  journal={The EMBO journal},
  year={2007},
  volume={26 5},
  pages={1245-56}
}
The p38 mitogen-activated protein kinase (MAPK) pathway plays a critical role in skeletal muscle differentiation. However, the relative contribution of the four p38 MAPKs (p38alpha, p38beta, p38gamma and p38delta) to this process is unknown. Here we show that myoblasts lacking p38alpha, but not those lacking p38beta or p38delta, are unable to differentiate and form multinucleated myotubes, whereas p38gamma-deficient myoblasts exhibit an attenuated fusion capacity. The defective myogenesis in… CONTINUE READING

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