Genetic analysis of lymphocyte activation by lipopolysaccharide Endotoxin.

  title={Genetic analysis of lymphocyte activation by lipopolysaccharide Endotoxin.},
  author={Barnet M. Sultzer},
  journal={Infection and immunity},
  volume={13 6},
A genetic study of in vitro lymphocyte blastogenesis by the B-cell mitogen lipopolysaccharide endotoxin has been performed, using both low-responder C3H/HeJ mice and high-responder CBA/J mice. The crossbreeding of these strains produced F1 progeny that were intermediate in responsiveness. Responder types from the backcross of the F1 to the C3H/HeJ strain segregated into intermediate- and low-responder phenotypes, whereas intermediate- and high-responder phenotypes were produced from the… CONTINUE READING
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