Genetic analysis of innate immunity.

@article{Hoebe2006GeneticAO,
  title={Genetic analysis of innate immunity.},
  author={Kasper Hoebe and Zhengfan Jiang and Koichi Tabeta and Xin Du and Philippe T Georgel and Karine Crozat and Bruce Beutler},
  journal={Advances in immunology},
  year={2006},
  volume={91},
  pages={
          175-226
        }
}
The inflammatory response to microbes--and host perception of microbes in general--is largely initiated by a single class of receptors, named for their similarity to the prototypic Toll receptor of Drosophila. The mammalian Toll-like receptors (TLRs) are ultimately responsible for most phenomena associated with infection. This includes both "good" effects of infection (e.g., the induction of lasting specific immunity to an infectious agent) and "bad" effects of infection (systemic inflammation… Expand
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