Genetic analysis of inherited hypertension in the rat.

@article{Rapp2000GeneticAO,
  title={Genetic analysis of inherited hypertension in the rat.},
  author={John P. Rapp},
  journal={Physiological reviews},
  year={2000},
  volume={80 1},
  pages={
          135-72
        }
}
Blood pressure is a quantitative trait that has a strong genetic component in humans and rats. Several selectively bred strains of rats with divergent blood pressures serve as an animal model for genetic dissection of the causes of inherited hypertension. The goal is to identify the genetic loci controlling blood pressure, i.e., the so-called quantitative trait loci (QTL). The theoretical basis for such genetic dissection and recent progress in understanding genetic hypertension are reviewed… CONTINUE READING
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