Genetic analysis of inflammation, cytokine mRNA expression and disease course of relapsing experimental autoimmune encephalomyelitis in DA rats.

@article{Lorentzen1997GeneticAO,
  title={Genetic analysis of inflammation, cytokine mRNA expression and disease course of relapsing experimental autoimmune encephalomyelitis in DA rats.},
  author={J C Lorentzen and Magnus L. Andersson and Shohreh Issazadeh and Ingrid Dahlman and Holger Luthman and Robert Weissert and Tomas Olsson},
  journal={Journal of neuroimmunology},
  year={1997},
  volume={80 1-2},
  pages={31-7}
}
Genetic analysis of experimental autoimmune encephalomyelitis (EAE) can provide clues to the etiology of multiple sclerosis (MS). Identifying the susceptibility genes of DA rats may be particularly rewarding since they are prone to develop a remarkably MS-like chronic and demyelinating disease. As a first step in this direction, we investigated the role of DA genes within and outside the major histocompatibility complex (MHC) for susceptibility to severe protracted and relapsing EAE (SPR-EAE… CONTINUE READING
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