Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infection.

@article{Yap2006GeneticAO,
  title={Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infection.},
  author={George S. Yap and Michael H. Shaw and Yun Ling and Alan Sher},
  journal={Microbes and infection},
  year={2006},
  volume={8 4},
  pages={
          1174-8
        }
}
Cell-mediated immunity to Toxoplasma gondii establishes and maintains a balanced host-pathogen relationship. Recent analyses using spontaneous and genetically engineered mouse mutants have yielded a clearer picture of factors positively and negatively regulating the host immune response and a better understanding of cytokine-inducible intracytoplasmic mechanisms that lead to intracellular pathogen suppression and demise. 

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