Genetic analysis of ectopic circadian clock induction in Drosophila.

@article{Kilman2009GeneticAO,
  title={Genetic analysis of ectopic circadian clock induction in Drosophila.},
  author={Valerie L. Kilman and Ravi Allada},
  journal={Journal of biological rhythms},
  year={2009},
  volume={24 5},
  pages={368-78}
}
Cell-autonomous feedback loops underlie the molecular oscillations that define circadian clocks. In Drosophila the transcription factor Clk activates multiple clock components of feedback loops many of which feed back and regulate Clk expression or activity. Previously the authors evoked similar molecular oscillations in putatively naïve neurons in Drosophila by ectopic expression of a single gene, Clk, suggesting a master regulator function. Using molecular oscillations of the core clock… CONTINUE READING

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