Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas.

  title={Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas.},
  author={Brian M. Kemp and Ripan Singh Malhi and John McDonough and Deborah A Bolnick and Jason A Eshleman and Olga Rickards and Cristina Mart{\'i}nez-Labarga and John R. Johnson and Joseph G. Lorenz and E. James Dixon and Terence E. Fifield and Tim H. E. Heaton and Rosita Worl and David Glenn Smith},
  journal={American journal of physical anthropology},
  volume={132 4},
Mitochondrial and Y-chromosome DNA were analyzed from 10,300-year-old human remains excavated from On Your Knees Cave on Prince of Wales Island, Alaska (Site 49-PET-408). This individual's mitochondrial DNA (mtDNA) represents the founder haplotype of an additional subhaplogroup of haplogroup D that was brought to the Americas, demonstrating that widely held assumptions about the genetic composition of the earliest Americans are incorrect. The amount of diversity that has accumulated in the… 

Figures and Tables from this paper

Skeletal variation among early Holocene North American humans: implications for origins and diversity in the Americas.

Results indicate that early Holocene males have variable postcranial morphologies, but all share the common trait of wide bodies, which provides support for a single, possibly high latitude location for the genetic isolation of ancestors of the human colonizers of the Americas.

Ancient DNA Analysis of Mid-Holocene Individuals from the Northwest Coast of North America Reveals Different Evolutionary Paths for Mitogenomes

Four ancient and three living individuals of the northern Northwest Coast of North America, specifically the north coast of British Columbia, Canada, current home to the indigenous Tsimshian, Haida, and Nisga’a, generated complete mitochondrial genomes (mitogenomes) to gain a better understanding of North American population history.

Discrepancy between Cranial and DNA Data of Early Americans: Implications for American Peopling

Comparing craniometric and mtDNA data of diachronic samples from East Central Argentina dated from 8,000 to 400 years BP shows that even when the oldest individuals display traits attributable to Paleoamerican crania, they present the same mtDNA haplogroups as later populations with Amerindian morphology.

An Alternative Model for the Early Peopling of Southern South America Revealed by Analyses of Three Mitochondrial DNA Haplogroups

The results indicate that the extant native populations inhabiting South Chile and Argentina are a group which had a common origin, and suggest a population break between the extreme south of South America and the more northern part of the continent.

Paternal origin of Paleo-Indians in Siberia: insights from Y-chromosome sequences

The analysis suggests that the in situ differentiation of Q-M242 in Central Eurasia and South Siberia region gave rise to numerous sub-lineages older than 15.3 kya, and the founding of Paleo-Indian paternal lineages is part of the great Q1-L53 diffusion throughout the Eurasia after the Last Glacial Maximum.

The Human Genetic History of the Americas: The Final Frontier




Ancient DNA and the biological history and prehistory of Northeastern North America

This study specializes in the recovery, identification, and analysis of DNA from degraded remains and is applied in two complementary areas: the interaction of genes, culture, and language in

Heterogeneity of mitochondrial DNA haplotypes in Pre-Columbian Natives of the Amazon region.

It is suggested that, in addition to the postulated bottleneck effect during the migration from Asia to the Americas, the depopulation effect started by European colonization in the 16th century contributed to the reduction in genetic variability of Amerindians.

Mesoamerica and Southwest prehistory, and the entrance of humans into the Americas : mitochondrial DNA evidence

These data demonstrate that widely held assumptions about the genetic composition of the earliest Americans are incorrect and that previous calibrations of the mtDNA clock may have seriously underestimated the rate of molecular evolution.

A single and early migration for the peopling of the Americas supported by mitochondrial DNA sequence data.

  • S. BonattoF. Salzano
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
Nucleotide diversity analyses based on haplogroup A sequences suggest that Native Americans and Chukchi originated from a single migration to Beringia that occurred approximately 30,000 or approximately 43,000 years ago, with 95% confidence intervals between approximately 22,000 and approximately 55,000 ago.

Ancient DNA analysis of Fremont Amerindians of the Great Salt Lake Wetlands.

Skeletal remains of 47 individuals from the Great Salt Lake Wetlands, affiliated principally with Bear River and Levee Phase Fremont cultural elements, were assessed for mitochondrial DNA markers that, in particular association, define four haplogroups widely shared among contemporary Amerindian groups.

Diversity and age of the four major mtDNA haplogroups, and their implications for the peopling of the New World.

The results put the peopling of the Americas clearly in an early, pre-Clovis time frame, extending the results initially found for haplogroup A to the three other major groups of mtDNA sequences found in the Americas.

MtDNA from extinct Tainos and the peopling of the Caribbean.

Sequence and haplogroup data show that the Tainos had a substantially reduced mtDNA diversity, which is indicative of an important founder effect during the colonization of the Caribbean Islands, assumed to have been a linear migratory movement from mainland South America following the chain configuration of the Antilles.

Asian affinities and continental radiation of the four founding Native American mtDNAs.

Observations suggest that the process of tribalization began early in the history of the Amerinds, with relatively little intertribal genetic exchange occurring subsequently.

Genetic Analysis of a Scytho-Siberian Skeleton and Its Implications for Ancient Central Asian Migrations

DNA extracted from a bone sample revealed a skeleton belonging to the Scytho-Siberian population and the resulting STR profile, mitochondrial haplotype, and haplogroup were compared with data from modern Eurasian and northern native American populations and were found only in European populations historically influenced by ancient nomadic tribes of Central Asia.

The genetic prehistory of Eastern North America : evidence from ancient and modern DNA

Mitochondrial DNA variation at the Pete Klunk Mound Group in Illinois suggests that Illinois Hopewell communities were matrilocal even though their burial practices were not influenced by matrilineal relationships, and provides no support for a hereditary or ascribed status system in Illinois Hopwell communities.