Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism

@article{Protas2006GeneticAO,
  title={Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism},
  author={Meredith E. Protas and Candace Hersey and Dawn M. Kochanek and Yi Zhou and Horst Wilkens and William R. Jeffery and Leonard I. Zon and Richard B. Borowsky and Clifford J. Tabin},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={107-111}
}
The genetic basis of vertebrate morphological evolution has traditionally been very difficult to examine in naturally occurring populations. Here we describe the generation of a genome-wide linkage map to allow quantitative trait analysis of evolutionarily derived morphologies in the Mexican cave tetra, a species that has, in a series of independent caves, repeatedly evolved specialized characteristics adapted to a unique and well-studied ecological environment. We focused on the trait of… 
Characterizing the genetic basis of trait evolution in the Mexican cavefish
TLDR
A pipeline to test individual fish for multiple traits provides a novel system to identify genes that underlie naturally occurring genetic variation in morphological and behavioral traits and reveals an association between body length and slower escape reflex in cavefish.
The complex origin of Astyanax cavefish
  • J. Gross
  • Biology, Medicine
    BMC Evolutionary Biology
  • 2012
TLDR
It is shown that cave forms originated from at least two distinct ancestral surface-dwelling stocks over the past several million years, and each stock gave rise to multiple invasions of the subterranean biotope.
Next generation phylogeography of cave and surface Astyanax mexicanus.
TLDR
A high-resolution phylogeography is reconstructed for Astyanax mexicanus cave populations from the Sabinos and Río Subterráneo caves and it is shown that theSabinos cave population is part of a unique cave lineage unrelated to other A. mexicansus populations.
Utilizing the blind cavefish Astyanax mexicanus to understand the genetic basis of behavioral evolution
  • J. Kowalko
  • Medicine, Biology
    Journal of Experimental Biology
  • 2020
TLDR
Astyanax mexicanus is an excellent model system for examining the genetic basis of complex traits and multiple avenues of new research that can be pursued using gene editing tools are identified, and how these will enhance the understanding of behavioral evolution is discussed.
A chromosome level genome of Astyanax mexicanus surface fish for comparing population-specific genetic differences contributing to trait evolution
TLDR
A high-resolution, chromosome-level surface fish genome is presented, enabling the first genome-wide comparison between surface fish and cavefish populations and confirming the essential role of a gene within an eye size QTL, rx3, in eye formation in A. mexicanus.
Evolutionary Genetics of Coloration in Primates and Other Vertebrates
TLDR
There has been good progress in identifying loci involved in the recent evolution of pigmentation in human populations, and variation in two key loci, MC1R (melanocortin-1 receptor) and ASIP (agouti signaling protein), can explain coat colour variation among species of lion tamarin.
Conservation and Convergence of Colour Genetics: MC1R Mutations in brown Cavefish
  • N. Mundy
  • Biology, Medicine
    PLoS genetics
  • 2009
TLDR
Different mutations at the same locus, MC1R (Melanocortin-1 receptor), underlie the parallel evolution of reduction of pigmentation in a teleost fish, the Mexican cave tetra Astyanax mexicanus, and add to a growing body of literature showing that genetic repeatability in evolution is surprisingly common.
The Population Genomics of Repeated Evolution in the Blind Cavefish Astyanax mexicanus
TLDR
The findings indicate that the repeatability of evolution at the genetic level is substantial, suggesting that ancestral standing genetic variation significantly contributed to the population genetic variability used in adaptation to the cave environment.
Convergence in feeding posture occurs through different genetic loci in independently evolved cave populations of Astyanax mexicanus
TLDR
Using the Mexican cavefish, Astyanax mexicanus, to study the genetic basis for convergent evolution of feeding posture, this work indicates that independently evolved populations of cavefish can evolve the same behavioral traits to adapt to similar environmental challenges by modifying different sets of genes.
Multi‐trait evolution in a cave fish, Astyanax mexicanus
TLDR
It is argued that at least some of the clusters must have a pleiotropic basis through quantitative trait loci mapping of 12 traits that differ significantly between the recently evolved Mexican cave tetra and its surface conspecific.
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