Genetic analysis of cadherin function in animal morphogenesis.

  title={Genetic analysis of cadherin function in animal morphogenesis.},
  author={Ulrich Tepass},
  journal={Current opinion in cell biology},
  volume={11 5},
Cadherins are a superfamily of Ca(2+)-dependent adhesion molecules found in metazoans. Several classes of cadherins have been defined from which two - classic cadherins and Fat-like cadherins - have been studied by genetic approaches. Recent in vivo studies in Caenorhabditis elegans and Drosophila show that cadherins play an active role in a number of distinct morphogenetic processes. Classic cadherins function in epithelial polarization, epithelial sheet or tube fusion, cell migration, cell… CONTINUE READING