Genetic analysis of audiogenic seizure susceptibility in C57BL/6J X DBA/2J recombinant inbred strains of mice.

@article{Seyfried1980GeneticAO,
  title={Genetic analysis of audiogenic seizure susceptibility in C57BL/6J X DBA/2J recombinant inbred strains of mice.},
  author={Thomas N. Seyfried and R K Yu and Gilbert H. Glaser},
  journal={Genetics},
  year={1980},
  volume={94 3},
  pages={701-18}
}
The inheritance of susceptibility to audiogenic seizures (ASs) was studied in the C57BL/6J (B6) and DBA/2J (D2) progenitor strains, their reciprocal F(1) hybrids, backcross generations and in 21 B6 x D2 recombinant inbred (RI) strains of mice at 21 days of age. All of the D2 mice tested experienced ASs, whereas none of the B6 mice responded to the sound. Although 23% of the F(1) mice experienced wild running, they were generally as resistant to ASs as their B6 parents. Mice of the F(1)x B6… CONTINUE READING

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