Genetic analysis of attractin homologs

@article{Walker2007GeneticAO,
  title={Genetic analysis of attractin homologs},
  author={Will P Walker and Swaroop Aradhya and Che-lin Hu and Shi-liang Shen and Wei Zhang and Arezou Azarani and Xin Yun Lu and Gregory S. Barsh and Teresa M. Gunn},
  journal={genesis},
  year={2007},
  volume={45}
}
Attractin (ATRN) and Attractin‐like 1 (ATRNL1) are highly similar type I transmembrane proteins. Atrn null mutant mice have a pleiotropic phenotype including dark fur, juvenile‐onset spongiform neurodegeneration, hypomyelination, tremor, and reduced body weight and adiposity, implicating ATRN in numerous biological processes. Bioinformatic analysis indicated that Atrn and Atrnl1 arose from a common ancestral gene early in vertebrate evolution. To investigate the genetics of the ATRN system and… Expand
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TLDR
It is proposed that MGRN1 and attractin are components of an evolutionarily conserved receptor trafficking pathway and that the md and mg mutations rescue the Ay phenotypes by a primarily cAMP-independent mechanism promoting trafficking of MC4R and likely MC1R away from the lysosome toward the cell surface. Expand
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Attractin gene deficiency contributes to testis vacuolization and sperm dysfunction in male mice
  • J. Li, Shiqi Wang, Shiyun Huang, D. Cheng, S. Shen, C. Xiong
  • Biology, Medicine
  • Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • 2009
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