Genetic analysis of atopy and asthma as quantitative traits and ordered polychotomies.

@article{Lawrence1994GeneticAO,
  title={Genetic analysis of atopy and asthma as quantitative traits and ordered polychotomies.},
  author={Scott Lawrence and Richard Beasley and I J M Doull and B Begishvili and Fiona Lampe and Stephen T. Holgate and Newton E. Morton},
  journal={Annals of human genetics},
  year={1994},
  volume={58 4},
  pages={
          359-68
        }
}
Traits related to atopy and asthma were defined in a random cohort of 131 families with three or more children. Correlation analysis provides no evidence of imprinting, maternal effect, or a major role of environment shared by sibs. Commingling analysis favours more than one distribution, the upper one being common for asthma and very common for atopy. Segregation analysis of rank-transformed variables provides only equivocal evidence of major genes against a polygenic background but suggests… CONTINUE READING

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