Genetic analysis of anal atresia in pigs: evidence for segregation at two main loci

@article{Cassini2004GeneticAO,
  title={Genetic analysis of anal atresia in pigs: evidence for segregation at two main loci},
  author={Pamela Cassini and Alberto Montironi and Sara Botti and Tetsuo Hori and Haruo Okhawa and Alessandra Stella and Leif Andersson and Elisabetta Giuffra},
  journal={Mammalian Genome},
  year={2004},
  volume={16},
  pages={164-170}
}
Anal atresia is a relatively common congenital malformation that occurs in about 1 out of 5000 infants, caused by abnormal hindgut development of the embryo, often associated with other developmental anomalies (e.g., Currarino, Townes–Brock, Pallister–Hall syndromes, and VATER association). Genetic analysis in human families is exceedingly difficult due to the multifactorial nature of the trait. In pigs, anal atresia occurs at a higher incidence (0.18%) than in humans. A complete genome scan… CONTINUE READING

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