Genetic analysis of absB, a Streptomyces coelicolor locus involved in global antibiotic regulation.

  title={Genetic analysis of absB, a Streptomyces coelicolor locus involved in global antibiotic regulation.},
  author={T Adamidis and Wendy C Champness},
  journal={Journal of bacteriology},
  volume={174 14},
The filamentous soil bacterium Streptomyces coelicolor is known to produce four antibiotics which are genetically and structurally distinct. An extensive search for antibiotic regulatory mutants led to the discovery of absB mutants, which are antibiotic deficient but sporulation proficient. Genetic analysis of the absB mutants has resulted in definition of the absB locus at 5 o'clock on the genetic map. Multiple cloned copies of the actII-ORF4 gene, an activator of synthesis of the antibiotic… CONTINUE READING

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