Genetic analysis of a new mouse model for non-insulin-dependent diabetes.

  title={Genetic analysis of a new mouse model for non-insulin-dependent diabetes.},
  author={J H Kim and Śaunak Sen and Caudrean Avery and E Hatheway Simpson and Phillip Chandler and Patsy M. Nishina and Gary A. Churchill and J{\"u}rgen K Naggert},
  volume={74 3},
The TallyHo (TH) mouse strain is a newly established model for non-insulin-dependent diabetes mellitus (NIDDM). TH mice show obesity, hyperinsulinemia, hyperlipidemia, and male-limited hyperglycemia. A genetic dissection of the diabetes syndrome has been carried out using male backcross 1 progeny obtained from crosses between (C57BL/6J x TH)F1 and TH mice or (CAST/Ei x TH)F1 and TH mice. A genome-wide scan reveals three quantitative trait loci (QTLs), Tanidd1-3 (TH-associated NIDDM) linked to… CONTINUE READING
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