Genetic analysis of SIGMAR1 as a cause of familial ALS with dementia


Amyotrophic lateral sclerosis (ALS) is the most common motor neuron diseases (MND), while frontotemporal lobar degeneration (FTLD) is the second most common cause of early-onset dementia. Many ALS families segregating FTLD have been reported, particularly over the last decade. Recently, mutations in TARDBP, FUS/TLS, and C9ORF72 have been identified in both… (More)
DOI: 10.1038/ejhg.2012.135


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