Genetic analysis of ID1-DBL2X predicts its validity as a vaccine candidate in Colombia and supports at least two independently introduced Plasmodium falciparum populations in the region.

Abstract

Pregnancy-associated malaria (PAM) poses a threat to both the mother and fetus, increasing the risk of severe maternal anemia, fetal growth restriction and low birth weight infants. Two vaccines are currently in development to protect women from Plasmodium falciparum in pregnancy. Both vaccine constructs target the ID1-DBL2X domain of VAR2CSA, a protein… (More)
DOI: 10.1016/j.meegid.2017.09.003

Topics

Cite this paper

@article{Rajwani2017GeneticAO, title={Genetic analysis of ID1-DBL2X predicts its validity as a vaccine candidate in Colombia and supports at least two independently introduced Plasmodium falciparum populations in the region.}, author={Jaya Rajwani and Christen M. Klinger and Eliana M. Arango and M. Arroyo and Abdulrahman Jafar Sabbagh and Ana M Maestre and Joel B. Dacks and S{\'e}dami Gnidehou and Stephanie K. Yanow}, journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases}, year={2017}, volume={55}, pages={175-185} }