Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies.

@article{Tagliafierro2017GeneticAO,
  title={Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies.},
  author={Lidia Tagliafierro and Omolara-Chinue Glenn and Madison E Zamora and Thomas Gerald Beach and Randy L. Woltjer and Michael W. Lutz and Ornit Chiba-Falek},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year={2017},
  volume={13 11},
  pages={
          1237-1250
        }
}
INTRODUCTION The α-synuclein (SNCA) gene has been implicated in the etiology of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). METHODS A computational analysis of SNCA 3' untranslated region to identify potential microRNA (miRNA) binding sites and quantitative real-time polymerase chain reaction (PCR) to determine their expression in isogenic induced pluripotent stem cell-derived dopaminergic and cholinergic neurons as a model of PD and DLB, respectively, were performed. In… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 11 times over the past 90 days. VIEW TWEETS