Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don't forget MEN1 genetic analysis.

@article{Cuny2013GeneticAI,
  title={Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don't forget MEN1 genetic analysis.},
  author={Thomas Cuny and Morgane Pertuit and Mona Sahnoun-Fathallah and Adrian F Daly and Gianluca Occhi and Marie Françoise Odou and Antoine Tabarin and Marie Laure Nunes and Brigitte Delemer and Vincent Rohmer and Rachel Desailloud and V{\'e}ronique Kerlan and Olivier Chabre and Jean-Louis Sadoul and Muriel Cogne and Philippe Caron and Christine Cortet-Rudelli and Anne Lienhardt and Isabelle Raingeard and A M Guedj and Thierry Brue and Albert Beckers and Georges Weryha and Alain Enjalbert and Anne Barlier},
  journal={European journal of endocrinology},
  year={2013},
  volume={168 4},
  pages={533-41}
}
CONTEXT Germline mutations in the aryl hydrocarbon receptor interacting protein gene (AIP) have been identified in young patients (age ≤30 years old) with sporadic pituitary macroadenomas. Otherwise, there are few data concerning the prevalence of multiple endocrine neoplasia type 1 (MEN1) mutations in such a population. OBJECTIVE We assessed the prevalence of both AIP and MEN1 genetic abnormalities (mutations and large gene deletions) in young patients (age ≤30 years old) diagnosed with… CONTINUE READING

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