Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

@inproceedings{Bras2014GeneticAI,
  title={Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies},
  author={Jose T Bras and R Guerreiro and Lee Darwent and L Parkkinen and Olaf Ansorge and Valentina Escott-Price and Dena G. Hernandez and Michael A. Nalls and Lorraine N. Clark and Lawrence S. Honig and Karen S. Marder and Wiesje Maria van der Flier and Afina W. Lemstra and Philip Scheltens and Ekaterina A. Rogaeva and Peter St George-Hyslop and Elisabet Y Londos and Henrik Zetterberg and Sara Ortega-Cubero and Pau Pastor and Tanis J. Ferman and Neill R. Graff-Radford and Owen A. Ross and Imelda S. Barber and Anne Braae and Kristelle S. Brown and Kevin A Morgan and Walter Maetzler and Daniela Berg and Claire Troakes and Safa Al-Sarraj and Tammaryn Lashley and Yaroslau Compta and Tamas R Revesz and Andrew Lees and Nigel J. Cairns and Glenda M Halliday and David Mann and Stuart M. Pickering-Brown and Dennis W. Dickson and Andrew Singleton and John Hardy},
  booktitle={Human molecular genetics},
  year={2014}
}
Clinical and neuropathological similarities between dementia with Lewy bodies (DLB), Parkinson's and Alzheimer's diseases (PD and AD, respectively) suggest that these disorders may share etiology. To test this hypothesis, we have performed an association study of 54 genomic regions, previously implicated in PD or AD, in a large cohort of DLB cases and controls. The cohort comprised 788 DLB cases and 2624 controls. To minimize the issue of potential misdiagnosis, we have also performed the… CONTINUE READING