Genetic analysis connects SLX5 and SLX8 to the SUMO pathway in Saccharomyces cerevisiae.

@article{Wang2006GeneticAC,
  title={Genetic analysis connects SLX5 and SLX8 to the SUMO pathway in Saccharomyces cerevisiae.},
  author={Zheng Wang and Grace Marie Jones and Gregory Prelich},
  journal={Genetics},
  year={2006},
  volume={172 3},
  pages={
          1499-509
        }
}
MOT1 encodes an essential ATPase that functions as a general transcriptional regulator in vivo by modulating TATA-binding protein (TBP) DNA-binding activity. Although MOT1 was originally identified both biochemically and in several genetic screens as a transcriptional repressor, a combination of subsequent genetic, chromatin immunoprecipitation, and microarray analysis suggested that MOT1 might also have an additional role in vivo as a transcriptional activator. To better understand the role(s… CONTINUE READING
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