Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4.

@article{Hosoda2017GeneticAO,
  title={Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4.},
  author={Waki Hosoda and Peter Chianchiano and James Freeland Griffin and Meredith E. Pittman and Lodewijk A A Brosens and Micha{\"e}l No{\"e} and Jun Yu and Koji Shindo and Masaya Suenaga and Neda Rezaee and Raluca Yonescu and Yi Ning and Jorge Albores-Saavedra and Naohiko Yoshizawa and Kenichi Harada and Akihiko Yoshizawa and Keiji Hanada and Shuji Yonehara and Michio Shimizu and Takeshi Uehara and Jaswinder Singh Samra and Anthony J Gill and Christopher L. Wolfgang and Michael G. Goggins and Ralph H. Hruban and Laura D Wood},
  journal={The Journal of pathology},
  year={2017},
  volume={242 1},
  pages={16-23}
}
High-grade pancreatic intraepithelial neoplasia (HG-PanIN) is the major precursor of pancreatic ductal adenocarcinoma (PDAC) and is an ideal target for early detection. To characterize pure HG-PanIN, we analysed 23 isolated HG-PanIN lesions occurring in the absence of PDAC. Whole-exome sequencing of five of these HG-PanIN lesions revealed a median of 33 somatic mutations per lesion, with a total of 318 mutated genes. Targeted next-generation sequencing of 17 HG-PanIN lesions identified KRAS… CONTINUE READING