Genetic alterations of CCND1 and EMSY in breast cancers.

  title={Genetic alterations of CCND1 and EMSY in breast cancers.},
  author={Tove Kirkegaard and Kirsten Vang Nielsen and Linda B Jensen and Fiona M. Campbell and Sven Oliver M{\"u}ller and Sian M. Tovey and Shelley Brown and Timothy G. Cooke and John M. S. Bartlett},
  volume={52 6},
AIMS CCND1 and EMSY, on 11q13, are frequently amplified in breast cancer. CCND1 is implicated in cell cycle progression and EMSY is a BRCA2-associated repressor protein. The aim was to investigate gene copy numbers of CCND1 and EMSY and to determine if CCND1 amplification is associated with reduced survival of tamoxifen-treated breast cancer patients. METHODS AND RESULTS Fluorescence in situ hybridization (FISH) was performed on 111 consecutive and 354 oestrogen receptor (ER)+ tamoxifen… CONTINUE READING


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