Genetic alterations in the ageing immune system: impact on infection and cancer.

@article{Effros2003GeneticAI,
  title={Genetic alterations in the ageing immune system: impact on infection and cancer.},
  author={Rita B. Effros},
  journal={Mechanisms of ageing and development},
  year={2003},
  volume={124 1},
  pages={71-7}
}
The immune system, which is able to distinguish between self and non-self, is programmed to protect the organism from a huge spectrum of potential foreign invaders. Each T and B lymphocyte bears an antigen receptor of a single specificity, which is determined during development by a unique genetic mechanism that generates millions of different variants of the genes encoding the receptor molecules. When a particular antigen, such as a virus, is encountered, only those lymphocytes bearing the… CONTINUE READING