Genetic alterations in squamous cell carcinomas of the hypopharynx with correlations to clinicopathological features.

@article{Rodrigo2002GeneticAI,
  title={Genetic alterations in squamous cell carcinomas of the hypopharynx with correlations to clinicopathological features.},
  author={Juan Pablo Rodrigo and Mar{\'i}a Victoria Rom{\'a}n Gonz{\'a}lez and Pedro S. Lazo and Sof{\'i}a Ramos and Eliecer Coto and I Villares Alvarez and Luis A. Garc{\'i}a and Carlos Ernesto Suarez},
  journal={Oral oncology},
  year={2002},
  volume={38 4},
  pages={357-63}
}
The objective of this study is to describe the molecular alterations in carcinomas in one specific location of the head and neck, the hypopharynx. Thirty-seven hypopharyngeal squamous cell carcinomas were studied. The DNA from tumour and healthy tissue was evaluated for amplification of the 11q13 region and of the MYC and ERBB1 oncogenes, for integration of the Human Papillomavirus (HPV), and for loss of heterozygosity (LOH) at p53 and NAT2 loci. The most common alteration was the amplification… CONTINUE READING

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