Genetic alterations in localized prostate cancer: identification of a common region of deletion on chromosome arm 18q.

@article{Latil1994GeneticAI,
  title={Genetic alterations in localized prostate cancer: identification of a common region of deletion on chromosome arm 18q.},
  author={Alain Latil and Jean François Baron and Olivier Cussenot and Georges Fournier and Thierry Soussi and Laurent Boccon-Gibod and Alain Le Duc and Jacques Ro{\"u}ess{\'e} and Rosette Lidereau},
  journal={Genes, chromosomes & cancer},
  year={1994},
  volume={11 2},
  pages={
          119-25
        }
}
Accumulation of mutations in oncogenes and tumor suppressor genes transforms a normal cell into a malignant cell by allowing it to escape from normal control of growth. In prostate tumorigenesis, the current model envisages specific mutations of the TP53 tumor suppressor gene and loss of loci, detected by loss of heterozygosity (LOH), on chromosome arms 8p, 10q, 16q, and 18q. In order to determine if alterations frequently found in other adenocarcinomas (breast, ovarian, gastric, colorectal… CONTINUE READING
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