Genetic alterations in gastric cancer: relation to histological subtypes, tumor stage, and Helicobacter pylori infection.

@article{Wu1997GeneticAI,
  title={Genetic alterations in gastric cancer: relation to histological subtypes, tumor stage, and Helicobacter pylori infection.},
  author={Ming-Shiang Wu and C. T. Shun and Hsiu Wang and J. C. Sheu and Woo Jung Lee and T. H. Wang and J. T. Lin},
  journal={Gastroenterology},
  year={1997},
  volume={112 5},
  pages={1457-65}
}
BACKGROUND & AIMS A different spectrum of genetic changes including p53, c-erbB-2, c-met, adenomatous polyposis coli (APC), and deleted in colorectal cancer (DCC) is involved in gastric cancer (GC). The aim of this study was to correlate these alterations with histological subtypes, tumor stages, and Helicobacter pylori infection. METHODS Specimens of 163 patients with GC were immunostained for p53, c-erbB-2, and c-met, and polymerase chain reaction was performed in them to determine loss of… CONTINUE READING

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