Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing?

@article{PuzianowskaKunicka2005GeneticAI,
  title={Genetic alterations in accelerated ageing syndromes. Do they play a role in natural ageing?},
  author={M Puzianowska-Kuźnicka and Jacek Kuźnicki},
  journal={The international journal of biochemistry & cell biology},
  year={2005},
  volume={37 5},
  pages={947-60}
}
The molecular mechanisms leading to human senescence are still not known mostly because of the complexity of the process. Different research approaches are used to study ageing including studies of monogenic segmental progeroid syndromes. None of the known progerias represents true precocious ageing. Some of them, including Werner (WS), Bloom (BS), and Rothmund-Thomson syndromes (RTS) as well as combined xeroderma pigmentosa-Cockayne syndrome (XP-CS) are characterised by features resembling… CONTINUE READING