Genetic alterations during the progression of squamous cell carcinomas of the uterine cervix.

@article{Kersemaekers1999GeneticAD,
  title={Genetic alterations during the progression of squamous cell carcinomas of the uterine cervix.},
  author={A. M. Kersemaekers and Marc Joan Van de Vijver and Gemma G Kenter and Gert Jan J Fleuren},
  journal={Genes, chromosomes & cancer},
  year={1999},
  volume={26 4},
  pages={346-54}
}
Most cervical carcinomas appear to arise from cervical intraepithelial neoplasia (CIN) lesions. In addition to infection with high-risk human papilloma viruses, which is indicative of an increased risk of progression, alterations of oncogenes and tumor suppressor genes play a role. Genetic studies of CIN lesions, primary cervical carcinoma, and metastases may shed light on the relative importance of various genetic alterations involved in the progression of CIN to invasive carcinoma. We… CONTINUE READING

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