Genetic alterations associated with cryptorchidism.

@article{Ferlin2008GeneticAA,
  title={Genetic alterations associated with cryptorchidism.},
  author={Alberto Ferlin and Daniela Zuccarello and Biagio Zuccarello and Maria Rosaria Chirico and Giovanni Franco Zanon and C Foresta},
  journal={JAMA},
  year={2008},
  volume={300 19},
  pages={2271-6}
}
CONTEXT Cryptorchidism is the most frequent congenital birth defect in male children and represents an important risk factor for infertility and testicular cancer. Major regulators of testicular descent are the hormones insulin-like factor 3 (INSL3) and testosterone, and disruption of these pathways might cause cryptorchidism. OBJECTIVE To determine the frequency of genetic alterations in cryptorchidism. DESIGN AND SETTING Case-control study in 2 departments of pediatric surgery in Italy… CONTINUE READING

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T 222 P mutation of the insulin - like 3 hormone receptor LGR 8 is associated with testicular maldescent and hinders recep - torexpressiononthecell surfacemembrane

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