Genetic alterations and their clinical implications in older patients with acute myeloid leukemia

@article{Tsai2016GeneticAA,
  title={Genetic alterations and their clinical implications in older patients with acute myeloid leukemia},
  author={Cheng-Hong Tsai and H A Hou and J Tang and C Liu and Cheng-Chieh Lin and W-C Chou and M-H Tseng and Y-C Chiang and Y-Y Kuo and M Liu and Changjian Liu and L Lin and Woei Tsay and Ming Yao and Chaofeng Li and S P Huang and B-S Ko and S C Hsu and C. T. A. Chen and C Lin and Shin-Jye Wu and H -F Tien},
  journal={Leukemia},
  year={2016},
  volume={30},
  pages={1485-1492}
}
A number of patient-specific and leukemia-associated factors are related to the poor outcome in older patients with acute myeloid leukemia (AML). However, comprehensive studies regarding the impact of genetic alterations in this group of patients are limited. In this study, we compared relevant mutations in 21 genes between AML patients aged 60 years or older and those younger and exposed their prognostic implications. Compared with the younger patients, the elderly had significantly higher… CONTINUE READING
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