Genetic alterations accumulate during cervical tumorigenesis and indicate a common origin for multifocal lesions.

@article{Larson1997GeneticAA,
  title={Genetic alterations accumulate during cervical tumorigenesis and indicate a common origin for multifocal lesions.},
  author={Amy A. Larson and S. Y. Liao and Eric John Stanbridge and Webster K Cavenee and Garrett M. Hampton},
  journal={Cancer research},
  year={1997},
  volume={57 19},
  pages={4171-6}
}
Carcinomas of the uterine cervix are thought to arise from preinvasive dysplastic lesions, termed cervical intraepithelial neoplasias (CIN), grades I-III. Patients may present clinically with two or more distinct lesions of differing histological severity; however, the genesis of these multifocal lesions is unknown. Despite infection with high-risk human papilloma virus subtypes, which is a major etiological factor in disease pathogenesis, only a small and unpredictable number of dysplastic… CONTINUE READING

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Changes in the physical state and expression of human papillomavirus type 16 in the progression of cervical intraepithelial neoplasia lesions analysed by PCR

  • B. Daniel, G. Mukhesjee, L. Seshadri, E. Vallikad, S. Krishna
  • J . Gen . Virol .
  • 1995

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