Genetic algorithm with alternating selection pressure for protein side-chain packing and pK(a) prediction

Abstract

The prediction of protein side-chain conformation is central for understanding protein functions. Side-chain packing is a sub-problem of protein folding and its computational complexity has been shown to be NP-hard. We investigated the capabilities of a hybrid (genetic algorithm/simulated annealing) technique for side-chain packing and for the generation of… (More)
DOI: 10.1016/j.biosystems.2011.05.013

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@article{Comte2011GeneticAW, title={Genetic algorithm with alternating selection pressure for protein side-chain packing and pK(a) prediction}, author={Pascal Comte and Sergei Vassiliev and Sheridan K. Houghten and Doug Bruce}, journal={Bio Systems}, year={2011}, volume={105 3}, pages={263-70} }