Genetic admixture of eight Mexican indigenous populations: Based on five polymarker, HLA‐DQA1, ABO, and RH loci

  title={Genetic admixture of eight Mexican indigenous populations: Based on five polymarker, HLA‐DQA1, ABO, and RH loci},
  author={Leonor Buentello-Malo and Rosenda I. Pe{\~n}aloza-Espinosa and Fabio Abdel Salamanca-G{\'o}mez and Ricardo M Cerda-Flores},
  journal={American Journal of Human Biology},
This study explores the genetic admixture of eight Mexican indigenous populations (Otomi‐Ixmiquilpan, Otomi‐Actopan, Tzeltales, Nahua‐Milpa‐Alta, Nahua‐Xochimilco, Nahua‐Zitlala, Nahua‐Ixhuatlancillo, and Nahua‐Coyolillo) on the basis of five PCR‐based polymorphic DNA loci (LDLR, GYPA, HBGG, D7S8, GC), HLA_DQA1, and the blood groups ABO and Rh (CcDEe). Among the indigenous populations, the highest gene frequencies for O and D were 0.9703 and 1.000 for Zitlala (State of Guerrero) and 0.9955 and… 

Characterization of mtDNA Haplogroups in 14 Mexican Indigenous Populations

The distribution of mtDNA haplogroups found in Mexican indigenous groups is similar to other Amerindian haplog groups, except for the African haplogroup found in one population.

Genetic structure of three Native Mexican communities based on mtDNA haplogroups, and ABO and Rh blood group systems.

No statistically-significant differences were found among the three populations studied or between them and 13 previously reported Native Mexican populations.

Mexican mestizo population sub-structure: effects on genetic and forensic statistical parameters

The results show that the Mexican mestizo population is substructured into three subgroups, which are in HW and linkage equilibrium, and the combination of the 15 loci in the whole population has high forensic efficiency and the capacity to genetically discriminate one individual in one quintillion.

The Mitochondrial DNA Landscape of Modern Mexico

Analysis of the mitochondrial DNA control region sequences revealed an overwhelming Native American legacy in the modern Mexican population, with ~90% of mtDNAs belonging to the four major pan-American haplogroups A2, B2, C1 and D1, which supports a European contribution to the Mexican gene pool primarily by male settlers and confirms the effectiveness of employing the uniparentally-transmitted mtDNA as a tool to reconstruct a country's history.

Dónde están los genomas de los mexicanos afrodescendientes

In Latin America it is currently estimated that 24 of every 100 individuals are of African descent. In Mexico, it is estimated that about 1,381,853 people are Afro-Mexican, which represents 1.2% of

Environmental and socio-cultural impacts on global DNA methylation in the indigenous Huichol population of Nayarit, Mexico

The results suggest that ethnicity, as well as other internal and environmental factors, might influence LINE-1 methylation.

The utility of genomic public databases to mitochondrial haplotyping in contemporary Mestizo population of Mexican origin.

AbstractThere are different public databases and open access information that can be exploited to be reused in different research projects. With this concept in mind, we carried out a study to answ...

The utility of genomic public databases to mitochondrial haplotyping in contemporary Mestizo population of Mexican origin

The objective of the present study was to explore the population structure of Mexico using available information in the public database of complete sequences of mitochondrial genome of indigenous people, Mexican Mestizo population and Mexican-Americans living in the United States.



Genetic structure of seven Mexican indigenous populations based on five polymarker loci

The demonstration of a relative genetic homogeneity of Mexican Indians for the markers studied suggests that this population is suitable for studying disease‐marker associations in the search for candidate genes of complex diseases.

Maximum likelihood estimates of admixture in northeastern Mexico using 13 short tandem repeat loci

Tetrameric short tandem repeat (STR) polymorphisms are widely used in population genetics, molecular evolution, gene mapping and linkage analysis, paternity tests, forensic analysis, and medical

Analysis of genotype frequencies and interlocus association for the PM, DQA1, and D1S80 loci in four populations.

The assumptions of Hardy-Weinberg and gametic equilibrium that facilitate the use of the five PM loci, DQA1 and D1S80 in forensic applications are consistent with the allele and genotype frequencies observed in these populations.

LMP2 and LMP7 gene polymorphism in Mexican populations: Mestizos and Amerindians

Genetic distances showed that Mexican Mestizos have an important relation with Spaniards and with all Mexican Amerindians, and could help to define the true significance of LMP polymorphism as genetic and evolutive marker in the Amerindian populations.

Distribution of HLA-B alleles in Mexican Amerindian populations

The HLA-B gene frequencies in 281 healthy individuals from four Mexican Amerindian populations analyzed by PCR-SSO technique corroborate the restricted polymorphism of H LA-B alleles and the high frequency of Hla-B35, HLA,B39 and HLA -B40 alleles in autochthonous American populations.

(AC)n Dinucleotide Repeat Polymorphism in 5' [Beta]-Globin Gene in Native and Mestizo Mexican Populations

The (AC)n repeat polymorphism in the b-globin gene has not been previously studied in Amerindian populations and it could be that the C allele occurs in low frequencies in the other groups as a result of small sample sizes.

Genetic differences at four DNA typing loci in Finnish, Italian, and mixed Caucasian populations.

The allele frequency distributions of some loci were found to differ significantly among the subpopulations in a manner consistent with population substructure, and major differences were found in the probability of occurrence of matching DNA profiles between two individuals chosen at random from the same subpopulation.

Allele frequency distributions at several variable number of tandem repeat (VNTR) and short tandem repeat (STR) loci in a restricted Caucasian population from south Italy and their evaluation for paternity and forensic use.

Most of the 11 STR loci examined can be analysed using allele frequencies from a general Caucasian reference population without typing subpopulations, whereas the VNTR loci must be subtyped.

The estimation of admixture in racial hybrids

  • R. Elston
  • Mathematics
    Annals of human genetics
  • 1971
Two main methods of estimating the relative contributions of parental contributions to a racial hybrid population when the traits involved are determined by a random set of independently assorting loci are reconsidered.