Genetic admixture of European FRDA genes is the cause of Friedreich ataxia in the Mexican population.

@article{Gmez2004GeneticAO,
  title={Genetic admixture of European FRDA genes is the cause of Friedreich ataxia in the Mexican population.},
  author={Maril{\'u}z G{\'o}mez and Rhonda M. Clark and Swapan K. Nath and Saeeda Bhatti and Rajesh Kumar Sharma and Elisa Alonso and Astrid Rasmussen and Sanjay I. Bidichandani},
  journal={Genomics},
  year={2004},
  volume={84 5},
  pages={779-84}
}
Friedreich ataxia accounts for approximately 75% of European recessive ataxia patients. Approximately 98% of pathogenic chromosomes have large expansions of a GAA triplet repeat in the FRDA gene (E alleles), and strong linkage disequilibrium among polymorphisms spanning the FRDA locus indicates a common origin for all European E alleles. In contrast, we found that only 14 of 151 (9.3%) Mexican Mestizo patients with recessive ataxia were homozygous for E alleles. Analysis of polymorphisms… CONTINUE READING
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