Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants.

@article{Ciofu2010GeneticAO,
  title={Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants.},
  author={Oana Ciofu and Lotte Frigaard Mandsberg and Thomas Bjarnsholt and Tina Wassermann and Niels H{\o}iby},
  journal={Microbiology},
  year={2010},
  volume={156 Pt 4},
  pages={
          1108-19
        }
}
During the chronic lung infection of patients with cystic fibrosis (CF), Pseudomonas aeruginosa can survive for long periods due to adaptive evolution mediated by genetic variation. Hypermutability is considered to play an important role in this adaptive evolution and it has been demonstrated that mutator populations are amplified in the CF lung by hitchhiking with adaptive mutations. Two of the genes that are frequently mutated in isolates from chronic infection are mucA and lasR. Loss-of… CONTINUE READING

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