Genetic activity of trichloroethylene in yeast.

  title={Genetic activity of trichloroethylene in yeast.},
  author={Giorgio Bronzetti and Errol Zeiger and Domenico Frezza},
  journal={Journal of environmental pathology and toxicology},
  volume={1 4},
Trichloroethylene (TCE) was tested for its ability to induce both point mutation and mitotic gene conversion in diploid strain of yeast. Saccharomyces cerevisiae (strain D7) was tested for both activities in culture with and without a mammalian microsomal activation system and in the intrasanguineous host-mediated assay in mice. Strain D4 (gene conversion) was tested only in the host-mediated assay. In suspension tests with D7, TCE was toxic but not genetically active without microsomal… CONTINUE READING

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