Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin.

@article{Powell2008GeneticAE,
  title={Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin.},
  author={Kim L. Powell and M Kyi and Christopher A. Reid and Lucy Paradiso and Giovanna M D'Abaco and Andrew H. Kaye and Simon J Foote and Terence J. O'Brien},
  journal={Neurobiology of disease},
  year={2008},
  volume={31 2},
  pages={261-5}
}
Stargazin is membrane bound protein involved in trafficking, synapse anchoring and biophysical modulation of AMPA receptors. A quantitative trait locus in chromosome 7 containing the stargazin gene has been identified as controlling the frequency and duration of absence seizures in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Furthermore, mutations in this gene result in the Stargazer mouse that displays an absence epilepsy phenotype. GAERS stargazin mRNA expression is increased 1… CONTINUE READING

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