Genetic abnormalities in sporadic parathyroid adenomas.

  title={Genetic abnormalities in sporadic parathyroid adenomas.},
  author={Eitan Friedman and A. Bale and Stephen J. Marx and Jeffrey A. Norton and Andrew O. Arnold and T H Tu and Gerald D. Aurbach and Allen M. Spiegel},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={71 2},
We analyzed genomic DNA from 43 sporadic benign parathyroid adenomas for rearrangements of the PTH gene, and for point mutations of the H-ras (codons 12, 13, and 61), N-ras (codons 12, 13, and 61), and K-ras (codons 12 and 13) genes. One of 43 parathyroid adenomas showed a chromosome 11 rearrangement involving both the PTH gene on the short arm of chromosome 11 (at band p15) and a locus on the long arm (11q13). This rearrangement was indistinguishable from one that was previously described in a… CONTINUE READING

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