Genetic abnormalities and challenges in the treatment of acute myeloid leukemia.

  title={Genetic abnormalities and challenges in the treatment of acute myeloid leukemia.},
  author={Christine A. C. Y. Kumar},
  journal={Genes & cancer},
  volume={2 2},
Acute myeloid leukemia (AML) is a hematopoietic disorder in which there are too many immature blood-forming cells accumulating in the bone marrow and interfering with the production of normal blood cells. It has long been recognized that AML is a clinically heterogeneous disease characterized by a multitude of chromosomal abnormalities and gene mutations, which translate to marked differences in responses and survival following chemotherapy. The cytogenetic and molecular genetic aberrations… CONTINUE READING


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