Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling

@article{Hoffman2006GeneticAO,
  title={Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling},
  author={Laura M. Hoffman and Christopher C. Jensen and Susanne Kloeker and C. A. Wang and Masaaki Yoshigi and Mary C Beckerle},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={172},
  pages={771 - 782}
}
Focal adhesions are specialized regions of the cell surface where integrin receptors and associated proteins link the extracellular matrix to the actin cytoskeleton. To define the cellular role of the focal adhesion protein zyxin, we characterized the phenotype of fibroblasts in which the zyxin gene was deleted by homologous recombination. Zyxin-null fibroblasts display enhanced integrin-dependent adhesion and are more migratory than wild-type fibroblasts, displaying reduced dependence on… CONTINUE READING