Genetic ablation of the transcription repressor Bach1 leads to myocardial protection against ischemia/reperfusion in mice.

@article{Yano2006GeneticAO,
  title={Genetic ablation of the transcription repressor Bach1 leads to myocardial protection against ischemia/reperfusion in mice.},
  author={Yoko Yano and Ryoji Ozono and Yoshihiko Oishi and Masayuki Kambe and Masao Yoshizumi and Takafumi Ishida and Shinji Omura and Tetsuya Oshima and Kazuhiko Igarashi},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2006},
  volume={11 7},
  pages={791-803}
}
Bach1 is a transcriptional repressor of heme oxygenase-1 gene (Hmox-1) and beta-globin gene. Heme oxygenase (HO)-1 is an inducible cytoprotective enzyme that degrades pro-oxidant heme to carbon monoxide (CO) and biliverdin/bilirubin, which are thought to mediate anti-inflammatory and anti-oxidant actions of HO-1. In the present study, we investigated the role of Bach1 in tissue protection against myocardial ischemia/reperfusion (I/R) injury in vivo using mice lacking the Bach1 gene (Bach1… CONTINUE READING